In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagno- sis, prevention and treatment of SCI.
DECEMBER, 2019 | PUBLICATIONS BY OUR TEAM MEMBERS
Immune responses generally decline with age. However, the dynamics of this process at the individual level have not been characterized, hindering quantification of an individual’s immune age. Here, we use multiple ‘omics’ technologies to capture population- and individual-level changes in the human immune system of 135 healthy adult individuals of different ages sam- pled longitudinally over a nine-year period.
MARCH, 2019 | PUBLICATIONS BY OUR TEAM MEMBERS
Despite clear differences in immune system responses and in the prevalence of autoimmune diseases between males and females, there is little understanding of the processes involved.
FEBRUARY 7TH, 2017 | PUBLICACTION BY OUR TEAM MEMBERS
Low-grade chronic inflammation has been associated with many of the diseases associated with aging, but the mechanisms that produce this inflammation are poorly understood.
JANUARY 16TH, 2017 | PUBLICACTION BY OUR TEAM MEMBERS
A longitudinal study reveals in older adults systemically reduced immune cell signaling responses that are stable at least 3 years and are predictive of cardiovascular disease.
OCTOBER 26TH, 2016 | PUBLICACTION BY OUR TEAM MEMBERS
Cytomegalovirus (CMV) is a b-herpesvirus present in a latent form in most people worldwide. In immunosuppressed individuals, CMV can reactivate and cause serious clinical complications, but the effect of the latent state on healthy people remains elusive.
APRIL 1ST, 2015, 2016 | PUBLICACTION BY OUR TEAM MEMBERS
There are marked differences between the sexes in their immune response to infections and vaccination, with females often having significantly higher responses.
JANUARY 14TH, 2014 | PUBLICACTION BY OUR TEAM MEMBERS
Inflammation has been found to be an underlying cause in many diseases, making it a hot topic in the health media. But what do we really know about chronic inflammation and its effects on the body?
JULY 29TH, 2015 | SCIENTIFIC LITERATURE
Markers of the systemic inflammatory response, including C-reactive protein and albumin, as well as neutrophil, lymphocyte and platelet counts have been shown to be prognostic of survival in patients with cancer. The aim of the present study was to examine the prognostic relationship between these markers of the systemic inflammatory response and all-cause, cancer, cardiovascular and cerebrovascular mortality in a large incidentally sampled cohort.
MARCH 2ND, 2015 | SCIENTIFIC LITERATURE
While modernization has dramatically increased lifespan, it has also witnessed the increasing prevalence of diseases such as obesity, hypertension, and type 2 diabetes. Such chronic, acquired diseases result when normal physiologic control goes awry and may thus be viewed as failures of homeostasis.
FEBRUARY 26TH, 2015 | SCIENTIFIC LITERATURE
Inflammation is classically recognized as an essential step for the control of microbial invasion or tissue injury as well as for the maintenance of tissue homeostasis under a variety of noxious conditions.
DECEMBER 30TH, 2010 | SCIENTIFIC LITERATURE